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Key vitamin deficiency linked to tripled risk of dementia: study
AFP ^ | February 5, 2008 | Unknown

Posted on 02/05/2008 2:12:13 PM PST by decimon

PARIS (AFP) - Lack of folate, also called vitamin B-9, may triple the risk of developing dementia in old age, according to a study published Tuesday.

Researchers in South Korea measured naturally occurring folate levels in 518 elderly persons, none of whom showed any signs of dementia, and then tracked their development over 2.4 years.

At the end of the period, 45 of the patients had developed dementia, including 34 diagnosed with Alzheimer's disease, said the study, published by the British Medical Association's Journal of Neurology, Neurosurgery and Psychiatry.

When the researchers, led by Jin-Sang Yoon of Chonnam National University in Kwangju, South Korea, remeasured folate levels, they uncovered a strong link with the dementia.

Even after other factors were taken into account -- including age, disability, alcohol consumption, weight change -- "the onset of dementia was significantly associated with an exaggerated decline in folate," the researchers concluded.

Folate and folic acid, another form of the compound, are essential for the creation of new cells in the body.

The compound occurs naturally in leafy vegetables such as spinach, turnip greens, lettuces, dried beans and peas and in certain fruits.

An study published last year in The Lancet showed an improvement in short-term memory, mental agility and verbal fluency among persons over 50 who took a daily dose of 800 micrograms (mcg) of folic acid. The US recommended daily dose is 400 mcg.

Taking folic acid before conception and throughout the first trimester helps a mother ensure that her child will not develop certain brain and spinal cord defects, including spina bifida, according to previous research.


TOPICS: Culture/Society; Miscellaneous; News/Current Events; Technical
KEYWORDS: dementia; dimentia; disorders; elderly; folicacid; nutraceuticals; nutriceuticals; supplements; vitamins
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This campaign season has me feeling de-folated.
1 posted on 02/05/2008 2:12:15 PM PST by decimon
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To: decimon

Quick, someone test McCain.


2 posted on 02/05/2008 2:13:21 PM PST by BubbaBasher (WWW.TWFRED08.COM)
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To: decimon

Nothing benign about B9. Or so I seem to recall.


3 posted on 02/05/2008 2:17:06 PM PST by Zuben Elgenubi
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To: BubbaBasher
Quick, someone test McCain.

Mandate folic acid for Senators.

4 posted on 02/05/2008 2:18:21 PM PST by decimon
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To: decimon

Well, FWIW, I take two so-called B-50 capsules a day, which adds up exactly to the recommended 800 mcg, plus various other types of vitamin Bs.

I think it’s also a good idea to take vitamin D in the winter when there’s not much sun.


5 posted on 02/05/2008 2:18:40 PM PST by Cicero (Marcus Tullius)
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To: BubbaBasher

Damn you beat me! LOL


6 posted on 02/05/2008 2:23:44 PM PST by pgkdan (Tolerance is the virtue of the man without convictions - G.K. Chesterton)
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To: Zuben Elgenubi
Nothing benign about B9.

Do you mean it is dangerous?

Regards

7 posted on 02/05/2008 2:28:53 PM PST by ARE SOLE (Agents Ramos and Campean are in prison at this very moment.. (A "Concerned Citizen".)
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To: Cicero
By consuming 800mcg folic acid, 400mcg B12 and 25mg B6 daily, you can completely methylate (and then urinate) an amino acid called homocysteine which is thought to cause hardening of the arteries in many people.

Next time you have your cholesterol checked, have the MD request the homocysteine test.

8 posted on 02/05/2008 2:32:04 PM PST by Zuben Elgenubi
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To: Lil'freeper

Ping


9 posted on 02/05/2008 2:34:28 PM PST by big'ol_freeper (REAGAN: "..party..must represent certain fundamental beliefs [not] compromised..[for] expediency")
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To: ARE SOLE

Playing on words, methinks.

B9 = bee nine = benign


10 posted on 02/05/2008 2:34:40 PM PST by decimon
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To: decimon

Doh ! Thanks


11 posted on 02/05/2008 2:35:23 PM PST by ARE SOLE (Agents Ramos and Campean are in prison at this very moment.. (A "Concerned Citizen".)
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To: ARE SOLE
Do you mean it is dangerous?

On the contrary. Since the article dealt with dementia, I added the second sentence:
Nothing benign about B9. Or so I seem to recall.
Which was supposed to parallel a demented state. I guess I'm not quite there yet, which is good.

12 posted on 02/05/2008 2:37:37 PM PST by Zuben Elgenubi
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To: decimon

Is it in beer? If so, I’m cool.


13 posted on 02/05/2008 2:38:15 PM PST by stevio ((NRA))
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To: Zuben Elgenubi
Which was supposed to parallel a demented state. I guess I'm not quite there yet...

Uhhh...

14 posted on 02/05/2008 2:39:40 PM PST by decimon
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To: decimon
At least this vitamin is easy to obtain for vegetarians.

Finding cheap palatable sources of vegetarian dha omega-3s in sufficient amounts cheaply is difficult.

15 posted on 02/05/2008 2:39:41 PM PST by Jedi Master Pikachu ( What is your take on Acts 15:20 (abstaining from blood) about eating meat? Could you freepmail?)
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To: ImaTexan

Ping


16 posted on 02/05/2008 2:43:04 PM PST by bjcintennessee (Don't Sweat the Small Stuff)
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To: decimon
dried beans and peas

The traditional Louisiana Monday eats, red beans and rice.

"Laissez Le Bon Ton Roulet"

'Tis Fat Tuesday (alias Mardi Gras).


17 posted on 02/05/2008 2:43:14 PM PST by capt. norm (Never underestimate the power of very stupid people in large groups.)
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To: stevio
Is it in beer? If so, I’m cool.

You're screwed. ;-)

"...beer is a good source of B vitamins[4]--in fact, beer is sometimes referred to as "liquid bread"[5]--although this may be less true for filtered beers[6]and the alcohol in beer impairs the body's ability to activate vitamins."

Wikipedia.

18 posted on 02/05/2008 2:44:57 PM PST by decimon
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To: decimon

btt


19 posted on 02/05/2008 2:45:15 PM PST by Cacique (quos Deus vult perdere, prius dementat ( Islamia Delenda Est ))
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To: decimon

Dang, I guess I have to drown my sorrows. Happy Fat Tuesday!


20 posted on 02/05/2008 2:59:23 PM PST by stevio ((NRA))
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To: Zuben Elgenubi
Next time you have your cholesterol checked, have the MD request the homocysteine test.

The research came out about 10 years ago on homocysteine - I take folic acid regularly.

I have noticed, over the years - and I have plenty of years to have noticed - that it takes an average of 20 years for viable studies to finally make it to implementation, i.e., you will hear about it from your doctor.

It behooves us to do own research - check and double check - and stick with reputable organizations studies.

AS for the heart, CoQ10 is another invaluable supplement.

Thing is, when something can be obtained without a prescription, and/or can't be patented, there won't be as much research or recommends from doctors.

Vegetables and fruits are the best sources for most of our requirements - BUT, unless you grow your own or get certified organic, they are grown in mineral depleted soil - so will not contain nature's intended levels.

Also, 'fresh' vegetables from the super market are not as fresh as frozen. Frozen vegs, are frozen straight out of the field - while 'fresh' vegs. are picked, processed, packed, loaded, trucked to maybe 2-3 warehouses before reaching your supermarkets warehouse - then gets shipped to your local store - and can still be additional days old before you bring them home. (The stores also have a dipping solution they use to reconstitute limp vegs) By the time they get on your plate, they have lost a good deal of nutrition.

Organic cost more out of pocket but gives you much better nutrition...saves money on doctor bills.

I have found that buying organic, particularly meats, it's more per pound - but by simply buying/eating less, I am getting better nutrition without spending more and, as a bonus, don't put on the weight.

21 posted on 02/05/2008 3:03:41 PM PST by maine-iac7 (",,,but you can't fool all of the people all the time" LINCOLN)
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To: Zuben Elgenubi
Berlin B9 Experimental Aircraft


22 posted on 02/05/2008 3:25:14 PM PST by Cobra64 (www.BulletBras.net)
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To: decimon

PLEASE NOTE: YOU MUST HAVE ENOUGH MAGNESIUM IN ORDER FOR ANY OF YOUR OTHER MINERALS AND SUPPLEMENTS TO ABSORB AND WE’RE ALMOST ALL DEFICIENT IN MAGNESIUM. TAKE AT LEAST 800MG/DAY.


23 posted on 02/05/2008 3:25:35 PM PST by spacejunkie
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To: Jedi Master Pikachu
Finding cheap palatable sources of vegetarian dha omega-3s in sufficient amounts cheaply is difficult.

Get flax seed, and grind it up (releasing the DHA/Omega-3s). Put hot water on it and make it into an 'oatmeal' like porridge.
Cheap and not entirely unpalatable...

24 posted on 02/05/2008 3:43:35 PM PST by El Cid (Believe on the Lord Jesus Christ, and thou shalt be saved, and thy house...)
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To: capt. norm

Shouldn’t that be les bons temps (I’m not talking about the song Bon Ton Rouley)


25 posted on 02/05/2008 3:58:26 PM PST by visualops (artlife.us nature wallpapers)
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To: El Cid
Get flax seed, and grind it up (releasing the DHA/Omega-3s).

Or you can buy flax seed oil capsules. Don't know the cost, but my GF is taking them.

26 posted on 02/05/2008 3:59:48 PM PST by AFreeBird (No Romney, No Rudy, No McLame, No Huck, No Paul! Toss the GOP into the ashcan of History.)
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To: decimon; neverdem

The fact that they didn’t warn that taking folic acid / folate could mask a B12 deficiency is infuriating. I have a B12 deficiency and it is linked to symptoms of dementia, alzheimers, depression etc.

Once you start getting the shots, the symptoms go away. All it takes is a simple blood test.


27 posted on 02/05/2008 4:06:01 PM PST by Patriotic1 (Dic mihi solum facta, domina - Just the facts, ma'am)
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To: Patriotic1
The fact that they didn’t warn that taking folic acid / folate could mask a B12 deficiency is infuriating.

IIRC, that's why folic acid is limited to doses of 400mcg.

28 posted on 02/05/2008 4:12:09 PM PST by decimon
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To: AFreeBird
Or you can buy flax seed oil capsules. Don't know the cost, but my GF is taking them.

Yes, that works also - but the capsules are a lot more expensive than buying flaxseed. Just buy one of those small coffee grinders (Proctor-Silex makes a small one for around $20), and grind up a Qtr cup of seeds a day and turn it into meal.
You don't need to worry about the oil going rancid, because the husk of the seed makes an excellent hermetic seal (I've heard claims that they've found flaxseed in 2000 year old cisterns that was still good for consumption). I presume the gel capsules make a good seal also, but probably not as good as the seed.
And although popping the pills are convenient, grinding flaxseed doesn't take very long and its a lot cheaper. You also get the added 'bonus' of fiber in your diet...Well, enough of my flaxseed advertisement...

29 posted on 02/05/2008 4:18:30 PM PST by El Cid (Believe on the Lord Jesus Christ, and thou shalt be saved, and thy house...)
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To: decimon
An study published last year in The Lancet showed an improvement in short-term memory, mental agility and verbal fluency among persons over 50 who took a daily dose of 800 micrograms (mcg) of folic acid. The US recommended daily dose is 400 mcg.

A decade ago the medical establishment would be calling 800 mcg. a "megadose" and offer stern warnings, demand stricter government controls, etc. etc.

30 posted on 02/05/2008 4:22:11 PM PST by denydenydeny (Expel the priest and you don't inaugurate the age of reason, you get the witch doctor--Paul Johnson)
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To: Bellflower; Bittersweetmd

ping!


31 posted on 02/05/2008 4:24:15 PM PST by sjeann
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To: decimon; Zuben Elgenubi

*GROAN*

For shame!


32 posted on 02/05/2008 4:27:49 PM PST by null and void (Conservatism. It's the new Black...)
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To: Patriotic1

Come to think of it, a well balanced B-Complex pill should cover the bases. But the other Bs would have to be limited in dosage to match the 400mcg of folic acid.


33 posted on 02/05/2008 4:28:08 PM PST by decimon
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To: Zuben Elgenubi

Interesting. My doctor, whom I greatly respect, has prescribed lipitor. So far no noticeable side effects, and he does yearly blood checks to be sure. I also take 80mg aspirin.


34 posted on 02/05/2008 4:32:55 PM PST by Cicero (Marcus Tullius)
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To: Cicero
My doctor wanted to put me on Lipitor; I flat out refused. My dad was on it for a while, and well, all sorts of problems. And then I found some info provided by a NASA astronaut/USAF flight surgeon/MD, that made me very, very wary of it.

Google "SpaceDoc"

35 posted on 02/05/2008 4:36:24 PM PST by AFreeBird (No Romney, No Rudy, No McLame, No Huck, No Paul! Toss the GOP into the ashcan of History.)
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To: decimon

Folic acid is importsnt throughout life, from pregnancy on. Deficiencies might not show up as problems through midlife but might pop up in later life.


36 posted on 02/05/2008 4:39:25 PM PST by RightWhale (oil--the world currency)
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To: visualops
Shouldn’t that be les bons temps

You're right. I lost my 's'.

It's OK, I have an appointment for an eye exam Friday....when I get back home with my new glasses, it'll all be like a big Easter egg hunt.

37 posted on 02/05/2008 5:32:22 PM PST by capt. norm (Never underestimate the power of very stupid people in large groups.)
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To: decimon
Lack of folate, also called vitamin B-9, may triple the risk of developing dementia in old age, according to a study published Tuesday. Researchers in South Korea measured naturally occurring folate levels in 518 elderly persons, none of whom showed any signs of dementia, and then tracked their development over 2.4 years.

I know an elderly woman who has received vitamin B shots... (kind I do not know) for years for dementia.

38 posted on 02/05/2008 5:36:17 PM PST by Just mythoughts (Isa.3:4 And I will give children to be their princes, and babes shall rule over them.)
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To: maine-iac7
Just got my blood chemistries last week. I've had cardio problems for the past ten years so I have my blood checked routinely. You are what you eat. And you are who you are (genetics).

The way I have it figured, in the Northern European climate of my ancestors, they lived a feast or famine lifestyle. Starve for a few days and then gorge when a kill was had. The liver produced fat in able to allow them to survive the bleak periods.

However in the past couple hundred years, three squares were more common. The 20th Century brought processed food (transfats, etc) and overeating.

So the survival mechanism that served my ancestors so well for thousands of years becomes a deadly genetic trait for a modern man without discipline.

39 posted on 02/05/2008 5:39:33 PM PST by Zuben Elgenubi
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To: Cobra64

Good one.


40 posted on 02/05/2008 5:40:42 PM PST by Zuben Elgenubi
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To: Cicero
Google CoQ10..and Lipitor. It's advised to take CoQ10 if you are on Lipitor.

sw

41 posted on 02/05/2008 5:44:52 PM PST by spectre (spectre's wife)
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To: Cicero
I've had bypass surgery so I'm especially aware of by blood chemistry which I have taken and examined by my cardiologist twice a year.

In 2000, I started off on 40mg/day of Lipator. My triglycerides were nearly 400.

Today, I'm on 10 mg/day of Lipitor and I take Coenzyme Q10 daily (to counter the possible negative effects of lipitor). Also the vitamin regimen I mentioned above. At surgery, my homocysteine level was nearly 14 mcg/litre and now it's 5.3 mcg/litre which is near baseline for humans. HDL of 56 and LDL of 67. This is the first time I've been able to get my LDL under 70, which for bypass people is a good number. Most of the population should be under 100.

Lipitor and exercise has risen my HDLs up from 35 at surgery. I also take a full aspirin once a day.

Point is, discuss with your MD. My vessels are clearly more diseased than yours so I divulge this information for comparative purposes, not as a recommendation.

From what I read, homocysteine is thought to contribute to dementia and the atheroscerosis are intimately associated. That's why I'm posting artery and heart information on a dementia thread.

I'm not a doctor but a Chemical Engineer so I can guarantee you that the methylation I refer to in my first post is valid.

42 posted on 02/05/2008 5:54:08 PM PST by Zuben Elgenubi
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To: Zuben Elgenubi
The way I have it figured, in the Northern European climate of my ancestors, they lived a feast or famine lifestyle. Starve for a few days and then gorge when a kill was had. The liver produced fat in able to allow them to survive the bleak periods.

However in the past couple hundred years, three squares were more common. The 20th Century brought processed food (transfats, etc) and overeating.

And studies on some Asian people with very long lives may very well help validate such a theory.

As for me; I'm a Northern European mutt, but I don't do the the three squares routine. I'm more of an eat when I'm hungry; eat until I've had my fill (I don't take home leftover either: science experiments in the fridge I don't need). So basically, I may or may not eat more smaller meals(food) more times a day. Only on occasion, special occasions at that, will I get even close to gluttony for a single meal.

43 posted on 02/05/2008 5:54:13 PM PST by AFreeBird (No Romney, No Rudy, No McLame, No Huck, No Paul! Toss the GOP into the ashcan of History.)
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To: spectre

You are correct. Very good topic to discuss with one’s physician.


44 posted on 02/05/2008 5:55:21 PM PST by Zuben Elgenubi
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To: AFreeBird
So basically, I may or may not eat more smaller meals(food) more times a day.

This is sound discipline.

45 posted on 02/05/2008 6:01:30 PM PST by Zuben Elgenubi
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To: Zuben Elgenubi
But it's expensive.

FWIW, CoQ10 can be purchased at Sams Club for almost half the price it is at health food stores.

sw

46 posted on 02/05/2008 6:03:29 PM PST by spectre (spectre's wife)
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To: spectre

Thank you, I’ll check that out. I’m going to watch “House” now. Hope they come up with a real medical mystery tonight. This guy would be fired the first day on the job in any real hospital. But I just love the show. G’nite.


47 posted on 02/05/2008 6:06:55 PM PST by Zuben Elgenubi
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To: decimon

ping


48 posted on 02/05/2008 6:13:17 PM PST by LadyPilgrim ((Jesus is real, He will never fail...I will serve him now, and throughout all eternity! ))
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To: Zuben Elgenubi
I don't know if I'd call it discipline so much as a feeling? I don't like feeling bloated, and I don't always feel the need to eat first thing in the morning (lunch is probably my more important meal of the day), and there are times when I have a craving for certain foods, or tastes (like salt for example).

I suspect it is a lot like a pregnant woman who has cravings. It's is more pronounced in her because two bodies are requesting certain nutrients, minerals, vitamins, et al.

The difference being; I'm not a woman, and I'm not pregnant, so the signals may be more subtle. But I guess I at least hear them.

49 posted on 02/05/2008 6:16:02 PM PST by AFreeBird (No Romney, No Rudy, No McLame, No Huck, No Paul! Toss the GOP into the ashcan of History.)
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To: AFreeBird
A common problem with oils in capsule form is that they go rancid. Rancid oils are worse than nothing.

Break open one of those caps and taste it. If it tastes bad or fishy, throw them out. See details at such places as Beware Rancid Fish Oil Capsules

I keep my oils in the refrigerator, in dark bottles, and don't hesitate to throw them out if they are starting to go south.

50 posted on 02/05/2008 6:27:14 PM PST by ThePythonicCow (The Greens and Reds steal in fear of freedom and capitalism; Fear arising from a lack of Faith.)
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