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Cure for killer bug - but there's a catch (Not for weak stomachs)
Scotsman ^ | Sun 14 Oct 2007 | KATE FOSTER

Posted on 10/30/2007 9:11:11 PM PDT by april15Bendovr

Cure for killer bug - but there's a catch KATE FOSTER

IN THE annals of medical history, this could go down as one of the most effective but stomach-churning treatments ever devised.

Scientists seeking a cure for a deadly superbug have successfully treated patients using human faeces.

Trials in a Scottish hospital have shown patients suffering from the Clostridium difficile bug can be cured using 'donor stool' administered via a tube through the nose into their stomach.

Clostridium difficile was last week at the heart of a damning report into cleaning failures at the Maidstone and Tunbridge Wells NHS Trust in Kent, which resulted in the deaths of 90 patients.

Around 6,000 Scots are affected every year by the severe and potentially fatal form of infectious diarrhoea. Six patients at the Victoria Infirmary in Glasgow are currently being treated for the infection in an isolation unit.

Clostridium difficile is a particular problem among patients who have been prescribed strong antibiotics as they also wipe out the so-called 'friendly' disease-fighting bacteria in the intestine. Faecal 'transplants', as they are known, are believed to restore the bacteria to levels at which they help the recovery process.

Doctors involved in the trials admit there are "obvious aesthetic problems" in the treatment, which involves patients ingesting a liquidised sample of faeces from a partner or close relative.

However, the treatment has the potential to save the lives of hundreds of patients infected with one of Britain's most serious hospital-acquired infections.

Traditional treatment of Clostridium difficile involves the use of antibiotics. But doctors at Glasgow's Gartnavel Hospital have conducted a trial of 'faecal transplants' on 12 patients for whom antibiotics had failed to stop repeated bouts of the infection.

Following the treatment, nine of the patients had no further incidents of the illness. One was initially cured but was later reinfected. The remaining two patients had a further bout but then responded well to antibiotics. A source close to the study said: "The antibiotics basically upset the delicate ecosystem within the gut and that allows the Clostridium difficile to take over and cause problems."

Faecal transplants allow doctors to reintroduce friendly bacteria into the gut, from a donor, using 30g of faeces. These recolonise the recipient's gut, restoring the health of the large intestine and killing off the bug.

The process takes about two weeks, during which donors are screened for suitability and other treatments are tried out. The key requirement is that donors should not have recently been on antibiotics themselves.

Doctors then mix the donated faeces with water to allow it to travel through a tube. Despite the positive results, doctors stress that they still regard the faecal transplant as a "last resort" because it is cumbersome and the idea of is unpleasant.

But Ian Poxton, professor of microbial infection and immunity at the University of Edinburgh and chair of the European Study Group on Clostridium difficile, said: "People with recurrent problems will try anything. This is patient driven.

"It involves a transplant from the spouse or another relative with a healthy gut. The donor is screened to make sure they do not have Clostridium difficile or anything that the patient would not want to catch."

He added: "There is something in the faeces that is working and the next step is to isolate that so that it could be made into a treatment."

Dr Alisdair MacConnachie, specialist registrar in infectious diseases at Gartnavel Hospital, presented a report on the new treatment to the Scottish Microbiology Society's symposium in Glasgow on hospital acquired infections.

MacConnachie decided to try the idea in 2003 with a patient with long-term recurring Clostridium difficile after a US study flagged up the idea.

His study is believed to be the first of its kind, and shows that the treatment can work on the clinical front-line.

The investigation concludes: "This technique is time consuming to set up and suffers from obvious aesthetic problems. However, it does offer a treatment to patients who have repeatedly failed to settle with conventional therapy." Clostridium difficile has been causing concern in recent years as it is far more difficult to kill through conventional hospital cleaning than MRSA. In Scotland, the number of sufferers who have died has risen in the past five years from 170 in 2001 to 313 in 2005.

Up to half of sufferers can experience repeated bouts despite antibiotic treatments.

Its spores can survive in the environment for a long time, resisting cleaning by detergents, and can spread from patient to patient. It is best controlled through regular handwashing with soap and water.

A Scottish Government spokeswoman said: "We would encourage boards to share any information on good practice when tackling infections such as Clostridium difficile."


TOPICS: News/Current Events
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I talking with a Doctor at work tonight and shared this FReeper article with him

French Dirt May Kill MRSA Local 6 ^ | POSTED: 9:45 am EDT October 26, 2007 | Research Teams Study Ancient Practice

Posted on 10/26/2007 12:52:30 PM EDT by poobear

He then shared with me this article.

1 posted on 10/30/2007 9:11:13 PM PDT by april15Bendovr
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To: april15Bendovr
Holy... crap!
2 posted on 10/30/2007 9:12:42 PM PDT by Bender2 ("I've got a twisted sense of humor, and everything amuses me." RAH Beyond this Horizon)
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To: april15Bendovr

An NG tube full of poop. Another miracle of socialized medicine.

I certainly hope this miracle cure wasn’t stumbled upon by accident.


3 posted on 10/30/2007 9:13:35 PM PDT by Triggerhippie (Always use a silencer in a crowd. Loud noises offend people.)
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To: april15Bendovr

Gives new meaning to the term “sh_t faced”.


4 posted on 10/30/2007 9:13:45 PM PDT by Rb ver. 2.0 (The WOT will end when pork products are weaponized)
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To: april15Bendovr; MeekOneGOP; Conspiracy Guy; DocRock; King Prout; Darksheare; OSHA; martin_fierro; ..
In other words, eat s*** and...live?


5 posted on 10/30/2007 9:14:10 PM PDT by Slings and Arrows ("Be deranged in a consistent manner. Manson was nuts, but at least he was always on message." --dead)
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To: april15Bendovr
ahhh - I think I'd try the crushed garlic in a cone first - it's even killed gangrene - been used for centuries.

crush garlic, put in cone like a pastry decorating bag and pass over (not connecting) the sore

6 posted on 10/30/2007 9:17:07 PM PDT by maine-iac7 ("...but you can't fool all of the people all of the time" LINCOLN)
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To: All

I just hope nobody is eating when they read this.


7 posted on 10/30/2007 9:17:10 PM PDT by april15Bendovr
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To: Bender2

8 posted on 10/30/2007 9:17:55 PM PDT by maine-iac7 ("...but you can't fool all of the people all of the time" LINCOLN)
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To: Rb ver. 2.0

Or “eat sh_t”...


9 posted on 10/30/2007 9:19:13 PM PDT by DB
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To: maine-iac7
Isn't garlic one of the only medications they have in Cuba?
10 posted on 10/30/2007 9:19:16 PM PDT by april15Bendovr
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To: april15Bendovr

Eat sh_t and LIVE!


11 posted on 10/30/2007 9:19:39 PM PDT by jwalsh07
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To: maine-iac7
and pass over (not connecting) the sore

Could you explain this? I'm a bit confused.

12 posted on 10/30/2007 9:20:56 PM PDT by CaptainK (...please make it stop. Shake a can of pennies at it.)
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To: jwalsh07; All
It disturbs me that this procedure is called a “Fecal Transplant”
13 posted on 10/30/2007 9:22:33 PM PDT by april15Bendovr
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To: maine-iac7
I try... to please--
14 posted on 10/30/2007 9:22:51 PM PDT by Bender2 ("I've got a twisted sense of humor, and everything amuses me." RAH Beyond this Horizon)
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To: LucyT

OK, how much do they charge for this? It must be pretty good s**t!


15 posted on 10/30/2007 9:22:53 PM PDT by Smokin' Joe (How often God must weep at humans' folly.)
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To: april15Bendovr

As soon as I read “fecal transplants”, I wish I hadn’t started reading...


16 posted on 10/30/2007 9:23:20 PM PDT by Santa Fe_Conservative
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To: Santa Fe_Conservative
Its a good thing I work in the medical field or I wouldn't be able to eat my pizza that I'm heating up in the oven.
17 posted on 10/30/2007 9:27:26 PM PDT by april15Bendovr
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To: Triggerhippie
I certainly hope this miracle cure wasn’t stumbled upon by accident.

Seems like a straight forward and logical treatment path considering the postulated cause.

MacConnachie decided to try the idea in 2003 with a patient with long-term recurring Clostridium difficile after a US study flagged up the idea.

Not Another miracle of socialized medicine.

18 posted on 10/30/2007 9:31:51 PM PDT by Pontiac (Your message here.)
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I have heard of fudge packing, but . . . Damn!


19 posted on 10/30/2007 9:33:28 PM PDT by Petruchio (Out to Lunch)
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To: april15Bendovr

Log Cabin Republicans will soon be touting this as part of the “therapeutic” relationship.


20 posted on 10/30/2007 9:39:05 PM PDT by Harrius Magnus (Pucker up Mo, and your dhimmi Leftist freaks, here comes your Jizya!)
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