Posted on 07/31/2006 11:39:55 AM PDT by markomalley
I don't understand what you mean - are you saying the school would give the vaccine and not disclose it to the parents? I sincerely doubt that would happen - it would be a HUGE lawsuit.
Yup
Girls already get BC w/o parental consent.
This medicine is a type of hormonal contraceptive commonly known as 'the mini pill' or progestogen-only pill (POP). It contains the active ingredient levonorgestrel, which is a synthetic progestogen, similar to the natural progestogens produced by the body
The progestogen-only pill prevents pregnancy in three ways.
Firstly, it affects the natural mucus at the neck of the womb (cervix). Levonorgestrel increases the thickness of this mucus, making it more difficult for sperm to cross from the vagina into the womb. By preventing sperm entering the womb, successful fertilisation of an egg, leading to pregnancy, is less likely.
Levonorgestrel also changes the quality of the womb lining (endometrium). The changes prevent any eggs that have been fertilised from successfully implanting onto the wall of the womb.
Lastly, levonorgestrel may prevent the release of an egg from the ovaries, however, this may not occur in all women who take the mini-pill.
Every other progesterone-only contraceptive has the same information provided. Plan "B" is the same thing...just a much stronger dosage. So the information provided by the pharmaceutical companies for all progesterone-only contraceptives is incorrect? They are ALL outdated? (particularly considering the political/sociological pressure that would be relieved if they could remove that statement from the insert)
I think it's more likely that this information is correct...
However, if you can provide me some source, I'll give it an honest look. If the information provided by the pharmaceutical companies that tells me that progesterone-only pills can be an abortifacient is incorrect, it's incorrect.
Girls already get BC w/o parental consent.
Yes, in many states, the laws are written so that minors can receive contraception without parental consent. It isn't written that way for vaccinations, however. Do some research before you post that minors will get Gardisil without consent. It's simply not true, unless laws are drastically changed.
This thread is about Plan B, not Gardisil.
This thread is about Plan B, not Gardisil.
Yes, but I wasn't the one who made the statement that schools were giving the vaccine without consent. I'm happy to let it go at this point.
>>>Yes, but I wasn't the one who made the statement that schools were giving the vaccine without consent. I'm happy to let it go at this point.
Nor was I. I linked where the poster got that thought from and also to establish that Plan B could be optainable through schools with clinics being established in them.
"And the public school system is automatically immunizing 11yr olds for STD's without parental consent"
I don't see where there is a mention of schools vaccinating 11 year olds, with or without consent.
Actually, this vaccination is given to pre adolescents because it is more effective if given before the girl reaches sexual maturity. I will get it for my daughter when it becomes available, as we have a history of ovarian and cervical cancer in my family. My daughter is 13 and she is not sexually active. I will tell her it is a vaccination for a virus that causes a type of cancer, which is all that she will want to know. I think this is a good thing. I also think you made up the part about schools giving vaccinations.
Thank you. That is interesting information. I have tried to find out more about this drug, but have been given so much contradictory information I almost gave up.
I am very pro life, and would not want to support something that causes a fertilized egg to be aborted. There is a lot of incorrect information floating around about Plan B. If I was confident that it would not harm an embryo, I think I could support this medication, especially in cases of rape or birth control failure.
Do you have a good and accurate source on this?
The most informative articles are Croxattoa, et al., Pituitary–ovarian function following the standard levonorgestrel emergency contraceptive dose or a single 0.75-mg dose given on the days preceding ovulation Contraception 70 (2004) 442–450
Durand, et. al., On the mechanisms of action of short-term levonorgestrel administration in emergency contraception. Contraception 64 (2001) 227–234
Seppala, et. al., Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation Endocrine Reviews 23 (4): 401-430 Copyright © 2002 by The Endocrine Society.
From what I understand from talking to one of the members, this information was presented at the FDA advisory committee meetings concerning Plan B.
Remember that one of the reasons for miscarriage is low progesterone and fertility docs often give progesterone to women early in pregnancy to support the pregnancy.
I can send you the articles, if you'd like. FReepmail with an address that accepts attachments.
Here's the abstracts
Pituitary–ovarian function following the standard levonorgestrel emergency contraceptive dose or a single 0.75-mg dose given on the days preceding ovulation
H.B. Croxattoa,*, V. Bracheb, M. Paveza, L. Cochonb, M.L. Forcelledoa, F. Alvarezb, R. Massaia, A. Faundesb, A.M. Salvatierraa aInstituto Chileno de Medicina Reproductiva, J.V. Lastarria 29, Department 101, Santiago, Chile bPROFAMILIA, Santo Domingo, Dominican Republic Received 30 December 2003; revised 17 March 2004; accepted 19 May 2004
Abstract We assessed to what extent the standard dose of levonorgestrel (LNG), used for emergency contraception, or a single dose (half dose), given in the follicular phase, affects the ovulatory process during the ensuing 5-day period. Fifty-eight women were divided into three groups according to timing of treatment. Each woman contributed with three treatment cycles separated by resting cycles. All received placebo in one cycle, and standard or single dose in two other cycles, in a randomized order. The diameter of the dominant follicle determined the time of treatment. Each woman had the same diameter assigned for all her treatments. Diameters were grouped into 33 categories: 12–14, 15–17 or 18–20 mm. Follicular rupture failed to occur during the 5-day period in 44%, 50% and 36% of cycles with the standard, half dose and placebo, respectively. Ovulatory dysfunction, characterized by follicular rupture associated with absent, blunted or mistimed gonadotropin surge, occurred in 35%, 36% and 5% of standard, single dose or placebo cycles, respectively.
In conclusion, LNG can disrupt the ovulatory process in 93% of cycles treated when the diameter of the dominant follicle is between 12 and 17 mm. It is highly probable that this mode of action fully accounts for the contraceptive efficacy as well as the failure rate of this method. The present data suggest that half the dose may be as effective as the standard dose.
D 2004 Elsevier Inc. All rights reserved.
On the mechanisms of action of short-term levonorgestrel administration in emergency contraception
Marta Duranda, Ma. del Carmen Craviotoa, Elizabeth G. Raymondb, Ofelia Dura´n-Sa´ncheza, Ma. De la Luz Cruz-Hinojosaa, Andre´s Castell-Rodrı´guezc, Raffaela Schiavond, Fernando Larreaa,* aDepartment of Reproductive Biology, Instituto Nacional de Ciencias Me´dicas y Nutricio´n Salvador Zubira´n, Mexico City, Mexico bFamily Health International, Research Triangle Park, NC, USA cDepartment of Cellular Biology, School of Medicine, Universidad Nacional Auto´noma de Me´xico, Mexico City, Mexico dReproductive Health Service, Instituto Nacional de Pediatrı´a, Mexico City, Mexico
Abstract
The effects of short-term administration of levonorgestrel (LNG) at different stages of the ovarian cycle on the pituitary-ovarian axis, corpus luteum function, and endometrium were investigated. Forty-five surgically sterilized women were studied during two menstrual cycles. In the second cycle, each women received two doses of 0.75 mg LNG taken 12 h apart on day 10 of the cycle (Group A), at the time of serum luteinizing hormone (LH) surge (Group B), 48 h after positive detection of urinary LH (Group C), or late follicular phase (Group D). In both cycles, transvaginal ultrasound and serum LH were performed from the detection of urinary LH until ovulation. Serum estradiol (E2) and progesterone (P4) were measured during the complete luteal phase. In addition, an endometrial biopsy was taken at day 9. Eighty percent of participants in Group A were anovulatory, the remaining (three participants) presented significant shortness of the luteal phase with notably lower luteal P4 serum concentrations. In Groups B and C, no significant differences on either cycle length or luteal P4 and E2 serum concentrations were observed between the untreated and treated cycles. Participants in Group D had normal cycle length but significantly lower luteal P4 serum concentrations. Endometrial histology was normal in all ovulatory-treated cycles. It is suggested that interference of LNG with the mechanisms initiating the LH preovulatory surge depends on the stage of follicle development.
Thus, anovulation results from disrupting the normal development and/or the hormonal activity of the growing follicle only when LNG is given preovulatory. In addition, peri- and post-ovulatory administration of LNG did not impair corpus luteum function or endometrial morphology. © 2001 Elsevier Science Inc. All rights reserved.
Endocrine Reviews 23 (4): 401-430 Copyright © 2002 by The Endocrine Society Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation Markku Seppälä, Robert N. Taylor, Hannu Koistinen, Riitta Koistinen and Edwin Milgrom Department of Obstetrics and Gynecology (M.S., H.K., R.K.), Helsinki University Central Hospital, Haartmaninkatu 2, 00029 HUS, Helsinki, Finland; Department of Obstetrics, Gynecology and Reproductive Sciences (R.N.T.), University of California, San Francisco, California 94143-0132; and Laboratoire d’Hormonologie et de Biologie Moleculaire (E.M.), Institute National de la Santé et de la Recherche Médicale Unité 135, Hormones, Genes et Reproduction, Hopital de Bicetre, 94275 Le Kremlin-Bicetre, France Correspondence: Address all correspondence and requests for reprints to: Markku Seppälä, Pihlajatie 20 B 15, 00270 Helsinki, Finland. E-mail: mseppala@pp.htv.fi
Glycodelin is a glycoprotein that belongs to the lipocalin superfamily. Depending on glycosylation, glycodelin appears in various isoforms. In the uterus, glycodelin-A is the major progesterone-regulated glycoprotein secreted into uterine luminal cavity by secretory/decidualized endometrial glands. The other tissues expressing glycodelin include fallopian tubes, ovary, breast, seminal vesicle, bone marrow, and eccrine glands.
Glycodelin-A potently and dose-dependently inhibits human sperm-egg binding, whereas differently glycosylated glycodelin-S from seminal plasma has no such effect. Absence of contraceptive glycodelin-A in the uterus during periovulatory midcycle is consistent with an open "fertile window."
Glycodelin induced by local or systemic administration of progestogens may potentially reduce the fertilizing capacity of sperm in any phase of the menstrual cycle. Glycodelin also has immunosuppressive activity. Its high concentration at the fetomaternal interface may contribute to protection of the embryonic semiallograft.
Besides being an epithelial differentiation marker, glycodelin appears to play a role in glandular morphogenesis, as transfection of glycodelin cDNA into a glycodelin-negative breast cancer cells resulted in formation of gland-like structures, restricted proliferation, and induction of other epithelial markers. These various properties, as well as the chemistry, biology, and clinical aspects of glycodelin, continue to be areas of active investigation reviewed in this communication.
It's not an end all for STDs or cervical cancer. It works on very few strains of HPV. Rather like Russian roulette in reverse.
Gee whiz, why don't they just make the standard birth control pill over the counter.
And Plan B is available on most college campuses already from the Quack Shacks funded by the state.
See my post above.
I'm still waiting to make up my mind, and would like to have more evidence. I've got about 5 articles that I think are pertinent.
Freepmail me if you want me to send them.
I think the cost of this vaccination is about $300 too. That is an awful lot of money to spend, and to cover up.
It works on HPV only, and it has the potential to prevent a majority of cervical cancer cases. Have you ever known anyone who died of cervical cancer? It is a horrible way to die. I can't understand anyone who wouldn't think that this vaccination is a good thing.
Maybe they should. The thinking, at any rate, is that if you have a medication prescribed over a long period of time, it is a good idea to have it monitored by a doctor. But in this case we're not talking about long term use, we're talking about occasional (ideally one-time) use. And the risks are miniscule. If advil is legal otc then so should the morning after pill.
I should add that nobody's talking about making this available over the counter in the strictest sense. On the contrary, it will be dispensed only by pharmacists, at their discretion, after asking questions about the patient to determine her identity, her medical history and if she is actually pregnant. This is what a doctor would do, it just speeds the process up (which makes it more likely that the woman will get contraceptives, rather than turn to an abortion).
No sorry I cannot.
But some one will, but it is all over the "certain flavor" news outlets.
Glen Beck (don't hit me) has been talking it up.
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