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Two Common Over-the-Counter Compounds Reduce COVID-19 Virus Replication by 99% in Early Testing
University of Florida ^ | 12 December 2021

Posted on 12/13/2021 4:32:16 AM PST by zeestephen

click here to read article


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To: zeestephen

Waiting for the democrat/media/big pharma/Faux-xi cheerleaders on here to say the death serum is perfectly safe with 98% efficacy.


21 posted on 12/13/2021 4:59:51 AM PST by wastedyears (The left would kill every single one of us and our families if they knew they could get away with it)
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To: Jan_Sobieski

The same dihydrogen monoxide used in nuclear reactors?!?!!?


22 posted on 12/13/2021 5:00:43 AM PST by wastedyears (The left would kill every single one of us and our families if they knew they could get away with it)
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To: wastedyears

^this


23 posted on 12/13/2021 5:01:25 AM PST by cport (How can political capital be spent on a bunch of ingrates)
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To: Celtic Conservative

Not exactly a perfectly harmless drug. It’s has strong anticholinergic side effects, especially in children and the elderly. You don’t want to gulp this stuff and drive, you may fall asleep behind the wheel. An older person may not be able to pee for a week and have instant Parkinson’s disease symptoms. There are much better antihistamines available. Read the warning label, they’re are much safer H1 blockers like Zyrtec. It’s far from a benign drug, especially in children where it can easily be lethal.


24 posted on 12/13/2021 5:04:12 AM PST by Babba Gi
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To: BusterDog

Be careful. Diphenhydramine is Benadryl, an antihistamine. Most common sleep aids contain an antihistamine, but many OTC sleep aids have an antihistamine OTHER THAN diphenhydramine (usually doxylamine).

Now, for sleeping, doxylamine = diphenhydramine, but the SARS CoV 2 inhibition of diphenhydramine (if it is true) may work a different way than the sleep-inducing properties.


25 posted on 12/13/2021 5:05:00 AM PST by Jim Noble (The nation cannot be saved until the GOP is destroyed)
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Next FReepathon Starts January 1st

Please Support FR
To Donate Hit The Button


26 posted on 12/13/2021 5:05:26 AM PST by DJ MacWoW (The Fed Gov is not one ring to rule them all)
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To: zeestephen

Bkmrk


27 posted on 12/13/2021 5:08:43 AM PST by RushIsMyTeddyBear (I'm in the control group. I identify as "vaccinated".🤡)
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To: mkmensinger

28 posted on 12/13/2021 5:10:44 AM PST by Bratch
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To: zeestephen

I think we’re going to find that EVERY cheap, simple medicine is effective against Covid. Except the one they’re pushing on us. LOL


29 posted on 12/13/2021 5:13:13 AM PST by Twotone (While one may vote oneself into socialism one has to shoot oneself out of it.)
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To: zeestephen

Awwww...that report is full of Swiss Cheese!


30 posted on 12/13/2021 5:17:13 AM PST by EBH (Never trust the government or a politician . 1776-2021 May God Save Us.)
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To: zeestephen

From the study:

“Lactoferrin from human milk was obtained…”

There are bovine lactoferrin options that would be fine. Other studies showed their efficacy.


31 posted on 12/13/2021 5:18:10 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: wastedyears

That stuff kill you dead


32 posted on 12/13/2021 5:20:54 AM PST by AppyPappy (Biden told Al Roker "America is back". Unfortunately, he meant back to the 1970's)
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To: Bratch

Careful kid, you’ll put an eye out


33 posted on 12/13/2021 5:21:37 AM PST by AppyPappy (Biden told Al Roker "America is back". Unfortunately, he meant back to the 1970's)
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To: cport; zeestephen

I wonder if they tried it with the OTC version of lactoferrin and it didn’t work, or did they purposely use the research type because it costs more, is regulated, and on UFs investment portfolio?
~~~~~~~~~~~~~~~~~~~~~~~~
Here is the original link where the medical paper is accessed….

https://www.mdpi.com/2076-0817/10/11/1514/htm

Pathogens is an international, peer-reviewed, open access journal of pathogens and pathogen-host interactions published monthly online by MDPI..... this is the “Multidisciplinary Digital Publishing Institute” and they are based in Switzerland. On Nov. 20, 2021, they put out this piece called “Highly Specific Sigma Receptor Ligands Exhibit Anti-Viral Properties in SARS-CoV-2 Infected Cells.”

Here is a copy and paste of I think is the heart of what this medical paper is saying in section 2.3 ... I don’t have time to review it again right now but I suspect that this sort of addresses the question you asked….

In our investigations into sigma-binding ligands, including diphenhydramine, we sought to reduce the EC50 by addition of another safe, and well characterized protein from milk, lactoferrin. The host-iron sequestration protein lactoferrin was reported to exhibit direct antiviral activity against SARS-CoV-2 [28,29], is broadly antimicrobial, and possesses host immunostimulatory properties. We tested combinations of lactoferrin with diphenhydramine to measure effects on reduction of EC50. Co-administration of 400 μg/mL of lactoferrin with diphenhydramine further reduced SARS-CoV-2 induced cytotoxicity and decreased the EC50 by 55.5% to 54.2 μg/mL (185.7 μM; Figure 8C,D). The antiviral enhancement effects of lactoferrin are more apparent at lower, therapeutically relevant concentrations of diphenhydramine (Figure 8E). Inhibition of viral replication was also investigated by qPCR (Figure 8F). Lactoferrin (400 μg/mL) was able to decrease N-protein RNA copies by 28.0% 48 h after infection, compared to DMSO alone controls while 40 μg/mL diphenhydramine alone resulted in 32.2% reduction. When combined, they inhibited 99.97% of N-protein RNA copies, a 3-log reduction that was highly significant. These data demonstrate that combinations of two over-the-counter compounds, with well characterized safety profiles, have synergistic effects on inhibition of SARS-CoV-2.


34 posted on 12/13/2021 5:28:32 AM PST by hecticskeptic
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To: MachIV

It’s generic and sold at Dollar Tree................


35 posted on 12/13/2021 5:37:18 AM PST by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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To: RummyChick
Study reveals existing drugs that kill SARS-CoV2 in cells (lactoferrin supplement best for safety and common availability), Aug 2021

The Efficacy and Safety of Ivermectin for Treatment and prophylaxis of COVID-19 Pandemic, Nov 2020 (Mentions lactoferrin)

Whey protein from human breastmilk inhibits SARS-CoV-2 infection, August 2020

36 posted on 12/13/2021 5:38:50 AM PST by ProtectOurFreedom (“…in any great disaster, there's a Harvard man in the middle of it.” ~ Thomas Sowell)
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To: zeestephen

When paired with lactoferrin, a protein found in cow and human milk, the compounds were found to hinder the SARS-CoV-2 virus during tests in monkey cells and human lung cells.

The FDA will soon require a doctor’s prescription for milk and recommend that newborn’s not be breastfed with this dangerous medically unapproved substance.


37 posted on 12/13/2021 5:39:37 AM PST by Flick Lives
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To: zeestephen
I've been drinking cow's milk from the farm for almost 40 years,

I'm 73 and I have never had any adverse affects from it.

38 posted on 12/13/2021 5:46:24 AM PST by knarf (?<p>Little kids grow up to be adults that get into powerful positions and act out their thoughts.<pg)
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To: BusterDog

Lactoferrin is only found in colostrum, the milk produced in the first 24 hours after a calf or baby has been born.


39 posted on 12/13/2021 5:50:01 AM PST by Madam Theophilus
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To: zeestephen

Is it just me, or doesn’t lactoferrin sound like a blend of milk and iron?


40 posted on 12/13/2021 5:57:28 AM PST by Migraine
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