Posted on 06/22/2019 7:36:13 PM PDT by SeekAndFind
Researchers at University of New Mexico researchers are working on a vaccine they hope could prevent Alzheimer's disease, reports CBS Albuquerque affiliate KRQE-TV. UNM's Health and Sciences Department Associate Professor Kiran Bhaskar, who's been passionate about studying the disease for the last decade, says the work started with an idea in 2013.
"I would say it took about five years or so to get from where the idea generated and get the fully functioning working vaccine," he said.
Bhaskar and his team started to test the vaccine on mice. It has not yet been shown if it works in people.
"We used a group of mice that have Alzheimer's disease, and we injected them over a series of injections," said PhD student Nicole Maphis. She said the vaccine targets a specific protein known as tau that's commonly found in the brains of Alzheimer's patients.
"These antibodies seem to have cleared (out) pathological tau. Pathological tau is one of the components of these tangles that we find in the brains of patients with Alzheimers disease," she explained. The response lasted for months, according to UNM.
Those long tangles "disrupt the ability of neurons to communicate with one another," the school points out, adding that tau is "normally a stabilizing structure inside of neurons."
The mice were then given a series of maze-like tests. The mice that received the vaccine performed a lot better than those that hadn't.
However, drugs that seem to work in mice do not always have the same effect in humans. A clinical trial involving people will be required to see if the drug helps in real life, and that's a difficult and expensive undertaking — with no guarantee of success.
(Excerpt) Read more at cbsnews.com ...
It is on both sides of my Family. Please let me test!
Ex wife’s grandfather had it, childhood best friend’s mom had it, bad stuff. The wife of a good friend of mine is in the same boat as you. Genes on both sides. Every time she forgets something it scares her. Allergic to darn near everything, she does keto diet in addition to gluten free and dairy free. Anything they say helps. It is a struggle. I pray the Lord lead these researchers to a cure.
President Trump’s ‘right to try’ drug bill offers the chance to try this drug on those desperate for a cure. Thank you President Trump.
Much of this now is being tied into nutritional deficiencies that build up over time into conditions diagnosed as diseases.
Tell your friend also to avoid any kind of head traumas or falls that smack the brain around. Blows to the head by something hitting them, or a fall where the head hots the ground, often is a trigger that causes the conditions to really start in earnest.
Amen!
[0014] We have discovered that triclabendazole (TCBZ) and fenbendazole (FBDZ) are effective in extending the lifespan of yeast and mammalian cells (a model for apoptosis), in increasing protection for cells from oxidative stress, and in protecting against diseases based on toxic protein aggregates or "proteinopathies," for example, Parkinson's disease and the related protein alpha-synuclein. Both triclabendazole and fenbendazole can be used to extend the lifespan of eukaryotic cells, protect cells from oxidative stress, and treat various neurodegenerative diseases that are known to involve toxic protein aggregates, for example, amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Parkinson's disease (PD), prion diseases, polyglutamine expansion diseases (e.g., Huntington's disease (HD)) and tauopathies (e.g., AD, frontotemporal dementia associated with tau-immunoreactive inclusions (FTD-tau), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD)). We have shown that that TCBZ and FBDZ increase the yeast chronological lifespan and protect yeast and mammalian cells from various stresses. In addition, both TCBZ and FBDZ decreased the level of cAMP in yeast and human cells. We believe the mechanism is by inhibiting the enzyme adenylate cyclase. In addition, we discovered that the human Parkinson's disease-related protein alpha-synuclein increased cAMP in yeast cells, and this increase could be inhibited by TCBZ. Thus both TCBZ and FBDZ can be used to treat Parkinson's disease. In addition, TCBZ and FBDZ can be used to treat symptoms of other diseases caused by protein aggregation (e.g., AD, HD, ALS, etc.). We believe that close derivatives or metabolites of either TCBZ or FBDZ would have similar effects. Known metabolites of TCBZ include a sulfoxide (TCBZ-SO) and a sulfone (TCBZ-S02). Similar metabolites of FBDZ include a sulfoxide (FBDZ-SO) and a sulfone (FBDZ-S02). In addition, since both TCBZ and FDBZ are low molecular mass compounds and hydrophobic, it is believed that both would cross the blood-brain barrier.
“Two hundred years ago it was not uncommon to deworm people.”
200 years ago most people died in their 40s.
L
Also, unrelated surgery can cause symptoms to worsen dramatically and never improve. I saw this happen. Referred to as post-operative delirium and other names, but tends to be permanent in the elderly. Often occurs after a broken hip and subsequent surgery.
A disease cannot be prevented without eliminating the cause.
The problem is that infinitely-stupid doctors, scientists & researchers have labeled Alzheimer’s a disease rather than a symptom.
The result will be expression of other symptoms (some of which are also labeled ‘disease’) as they seek to mask the symptom with yet another drug.
Aging is highly-profitable, don’t you know. So is ‘treating’ disease...
“You are not suggesting anti-parasitic drugs reduced the lifespan of the population 200 years ago, are you?“
I’m suggesting that the use of these crude drugs did almost nothing to improve lifespan 200 years ago. Improve and reduce are two different things.
I suggest you obtain a dictionary.
L
Here on FR a few weeks ago, this an animal de-wormer was discussed to counter cancer.
Shoot, if I were desperate I’d probably give it a shot.
Also a while back there was discussion about diatomaceous earth as a cure or prevention for something along these lines, IIRC.
“Anti-parasitics are part of contemporary world-wide health initiatives”
Not for cancer.
L
“Was the article regarding the Joe Tippens story?”
Not sure re Tippens. I recall that I did read up on DE at that time. Very interesting, though.
My father-in-law had it, and it’s the one thing that scares my wife.
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