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Israeli scientists 'print' world's first 3D heart with human tissue
Jerusalem Post ^ | April 15, 2019 17:37 | By Maayan Jaffe-Hoffman

Posted on 04/15/2019 2:28:19 PM PDT by Red Badger

A team of Israeli researchers has “printed” the world’s first 3-D vascularized, engineered heart.

On Monday, a team of Tel Aviv University researchers revealed the heart, which was made using a patient’s own cells and biological material. Until now, scientists have successfully printed only simple tissues without blood vessels. “This is the first time anyone anywhere has successfully engineered and printed an entire heart replete with cells, blood vessels, ventricles and chambers,” said Prof. Tal Dvir of TAU’s School of Molecular Cell Biology and Biotechnology, Department of Materials Science and Engineering in the Center for Nanoscience and Nanotechnology, and the Sagol Center for Regenerative Biotechnology, who was the lead researcher for the study.

He worked with Prof. Assaf Shapira of TAU’s Faculty of Life Sciences, and Nadav Moor, a doctoral student. Their research was published in Advanced Science.

Heart disease is the leading cause of death among both men and women in the United States. In Israel, it is the second largest cause of death (after cancer). In 2013, heart disease accounted for about 16% of the total number of deaths in Israel, according to the Health Ministry.

Heart transplantation is often the only treatment available to patients with end-stage heart failure. The waiting list for patients in the US can be as much as six months or more. In Israel and the US, many patients die while on the waiting list, hoping for a chance at survival.

“This heart is made from human cells and patient-specific biological materials. In our process, these materials serve as the bio-inks, substances made of sugars and proteins that can be used for 3-D printing of complex tissue models,” Dvir explained.

“People have managed to 3D-print the structure of a heart in the past, but not with cells or with blood vessels. Our results demonstrate the potential of our approach for engineering personalized tissue and organ replacement in the future,” he said.

At this stage, the 3-D heart produced at TAU is sized for a rabbit, but the professors said that larger human hearts could be produced using the same technology.

For the research, a biopsy of fatty tissue was taken from patients, according to a release. The cellular and a-cellular materials of the tissue were then separated. The cells were reprogrammed to become pluripotent stem cells that could then be efficiently differentiated into cardiac or endothelial cells. The extracellular matrix (ECM), a three-dimensional network of extracellular macromolecules, such as collagen and glycoproteins, was processed into a personalized hydrogel that served as the printing “ink.” The differentiated cells were then mixed with the bio-inks and were used to 3D-print patient-specific, immune-compatible cardiac patches with blood vessels and, subsequently, an entire heart.

According to Dvir, the use of “native” patient-specific materials is crucial to successfully engineering tissues and organs.

The next step, they said, is to teach the hearts to behave like human hearts. First, they will transplant them into animals and eventually into humans. The hope is that within “10 years, there will be organ printers in the finest hospitals around the world, and these procedures will be conducted routinely,” Dvir said.


TOPICS: Arts/Photography; Health/Medicine; Science; Society
KEYWORDS: 3dheart; 3dprinter; health; heart
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Video at link....................
1 posted on 04/15/2019 2:28:19 PM PDT by Red Badger
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To: Red Badger

I will bless those who bless you, and whoever curses you I will curse; and all peoples on earth will be blessed through you. Genesis 12:3


2 posted on 04/15/2019 2:38:56 PM PDT by InkStone (Omni Vivum Ex Surfboard)
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To: Red Badger

For the research, a biopsy of fatty tissue was taken from patients, according to a release. The cellular and a-cellular materials of the tissue were then separated. The cells were reprogrammed to become pluripotent stem cells that could then be efficiently differentiated into cardiac or endothelial cells.

...

Does anybody remember when we were told of how medical science would come to a stand still without embryonic stem cells? The leftist ghouls were beating that drum every day.


3 posted on 04/15/2019 2:46:50 PM PDT by Moonman62 (Facts are racist.)
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To: Moonman62

Yes, they lied, as per usual..................


4 posted on 04/15/2019 2:50:09 PM PDT by Red Badger (We are headed for a Civil War. It won't be nice like the last one....................)
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To: Red Badger
A team of Israeli researchers has “printed” the world’s first 3-D vascularized, engineered heart.

Meanwhile a team of Arab researchers worked on a way to turn Chinese electronics into a better car bomb trigger.

5 posted on 04/15/2019 2:53:26 PM PDT by KarlInOhio (Leave the job, leave the clearance. It should be the same rule for the Swamp as for everyone else.)
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To: Red Badger

I’ll let Mikey try it first, thanks.


6 posted on 04/15/2019 3:08:55 PM PDT by NormsRevenge (Semper Fi - Monthly Donors Rock!!!)
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To: KarlInOhio

The best post I’ve seen so far this year!


7 posted on 04/15/2019 3:13:54 PM PDT by chickenlips
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To: Red Badger

Can’t wait to try out the organ printers when they come to Walmart. Not sure about the install.


8 posted on 04/15/2019 3:35:53 PM PDT by fruser1
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To: Moonman62

+1


9 posted on 04/15/2019 3:36:13 PM PDT by ak267
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To: InkStone

‘I will bless those who bless you, and whoever curses you I will curse; and all peoples on earth will be blessed through you. Genesis 12:3.”

Amen and amen. GOD bless ISRAEL AND THE JEWISH PEOPLE.


10 posted on 04/15/2019 3:52:51 PM PDT by kagnew
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To: kagnew

Amen.


11 posted on 04/15/2019 4:10:35 PM PDT by V V Camp Enari 67-68 (Viet Vet)
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To: Red Badger

I think the Arab world which outnumbers Jewish people 100 to 1 has earned about 4 Nobel Prizes, compared to their 130 or something.


12 posted on 04/15/2019 4:17:26 PM PDT by Telepathic Intruder
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To: Red Badger

Please don’t tell Hillary that she can now have a heart.


13 posted on 04/15/2019 4:22:54 PM PDT by Ancesthntr ("The right to buy weapons is the right to be free." A. E. van Vogt, The Weapons Shops of Isher)
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To: Red Badger

Not available for BDS supporters.


14 posted on 04/15/2019 4:34:56 PM PDT by BTerclinger (MAGA)
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To: KarlInOhio; Red Badger; BTerclinger

A team of Israeli researchers has “printed” the world’s first 3-D vascularized, engineered heart.

Meanwhile a team of Arab researchers worked on a way to turn Chinese electronics into a better car bomb trigger. <<<

Excellent post. People might criticize ancient Israel for not following God's instructions. They didn't wipe out the Canaanites, Saul spared the king of Amalek, on and on. They didn't listen! Story of their life...

But you know... what would the Ishmaelites done given those same blanket instructions to kill off entire nations? Anyone think they would have hestitated? Now there's command that a certain type of people would carry out with glee. They'd be all over it like flies on ****.

But Israel... had a real problem with killing people. Just not in their nature. Israel... wants people to live.

That's kind of a 'tell' about who God's people are, the apple of His eye.

AM ISRAEL CHAI

15 posted on 04/15/2019 4:37:41 PM PDT by Ezekiel (The pun is mightier than the s-word.)
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To: KarlInOhio; Ezekiel

Winner.


16 posted on 04/15/2019 9:17:14 PM PDT by BTerclinger (MAGA)
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To: fruser1

Gives the BSOD a whole new meaning.......................


17 posted on 04/16/2019 6:20:08 AM PDT by Red Badger (We are headed for a Civil War. It won't be nice like the last one....................)
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To: Ezekiel

The Israelites and Ishmaelites (modern day Arabs)are the progeny of Abraham.

Abraham was a very kindhearted man. He even wanted to save Sodom and Gomorrah from destruction, and ‘bargained’ with God for its salvation, but it was not enough.

Ishmaelites were Abraham’s progeny as well, but their genes must have been predominately from Hagar, the EGYPTIAN handmaid of Sarah. They inherited from her a predisposition of violence and conniving treachery.

For 3000 years it has been this way...................


18 posted on 04/16/2019 6:45:19 AM PDT by Red Badger (We are headed for a Civil War. It won't be nice like the last one....................)
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To: BTerclinger

Bush Derangement Syndrome?.......................


19 posted on 04/16/2019 7:00:37 AM PDT by Red Badger (We are headed for a Civil War. It won't be nice like the last one....................)
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To: Ancesthntr

If she only had a brain...................


20 posted on 04/16/2019 7:01:09 AM PDT by Red Badger (We are headed for a Civil War. It won't be nice like the last one....................)
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