Heavier bullets tend to penetrate deeper than lighter ones. Not that 5 grains will make all that much difference. Id recommend that you get 100 of each cartridge (yes thats expensive) and fire all of them through your pistol.
What youre testing for is reliabilityand accuracy. Either load will be fine for self defense purposes, but reliability is of paramount importance.
If you get any failures to feed reliably dont use that ammunition.
Yes it does...