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New England Journal of Medicine, Emergence of Zaire Ebola Virus Disease in Guinea
New England Journal of Medicine ^ | October 9, 2014

Posted on 10/11/2014 5:54:43 PM PDT by wtd

Abstract

In March 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Full-length genome sequencing and phylogenetic analysis showed that EBOV from Guinea forms a separate clade in relationship to the known EBOV strains from the Democratic Republic of Congo and Gabon. Epidemiologic investigation linked the laboratory-confirmed cases with the presumed first fatality of the outbreak in December 2013. This study demonstrates the emergence of a new EBOV strain in Guinea.

(Excerpt) Read more at nejm.org ...


TOPICS: Chit/Chat
KEYWORDS: 201403; disease; ebola; ebov; emergence; guinea; strain; virus; zaire
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Caveat: I don't read Greek (or Latin or gyberish)-

-none-the-less, this report doesn't bode well for open societies.

1 posted on 10/11/2014 5:54:43 PM PDT by wtd
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To: wtd
Doctor in Liberia Explains MILLIONS Wasted in Ebola Fight

Liberia is losing the fight against Ebola because they are depending on NGOs and an influx of Western money instead of traditional ways of dealing with epidemics. The first few Ebola epidemics were in remote villages where the villages touched by Ebola were self-quarantined according to ancient traditions of dealing with plagues. No one went in and out, and the surrounding communities brought them food. The caregivers washed themselves and their clothes rapidly and frequently after each contact with the patient, just using simple soap and water. Very few ever got sick, and the disease was controlled in a few months.

Here in Liberia, everyone is excited about the millions of US dollars being poured in to “fight Ebola,” and everyone wants a piece of the pie.

Read the rest at the link

2 posted on 10/11/2014 5:58:10 PM PDT by wtd
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To: wtd

The clinical picture of the initial cases was predominantly
fever, vomiting, and severe diarrhea. Hemorrhage was not
documented for most of the patients with confirmed disease
at the time of sampling but may have developed later in
the course of the disease. The term Ebola virus disease
(rather than the earlier term Ebola hemorrhagic fever)
takes into account that hemorrhage is not seen in all
patients15 and may help clinicians and public health
officials in the early recognition of the disease.
The case fatality rate was 86% among the early confirmed
cases and 71% among clinically suspected cases, which is
consistent with the case fatality rates observed in
previous EBOV outbreaks.15-17

Potential reservoirs of EBOV, fruit bats of the species
Hypsignathus monstrosus, Epomops franqueti,
and Myonycteris torquata, are present in large parts of
West Africa.


3 posted on 10/11/2014 6:00:59 PM PDT by Diogenesis (The EXEMPT Congress is complicit in the absence of impeachment)
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To: wtd

Thanks for posting. Health/life BUMP!


4 posted on 10/11/2014 6:04:30 PM PDT by PGalt
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To: wtd; neverdem; ProtectOurFreedom; Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; ...
Bring Out Your Dead

Post to me or FReep mail to be on/off the Bring Out Your Dead ping list.

The purpose of the “Bring Out Your Dead” ping list (formerly the “Ebola” ping list) is very early warning of emerging pandemics, as such it has a high false positive rate.

So far the false positive rate is 100%.

At some point we may well have a high mortality pandemic, and likely as not the “Bring Out Your Dead” threads will miss the beginning entirely.

*sigh* Such is life, and death...

5 posted on 10/11/2014 6:16:14 PM PDT by null and void ("Agoraphobia": fear of the marketplace; "AlGoreaphobia": fear of the marketplace of ideas.)
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To: Smokin' Joe

Ping


6 posted on 10/11/2014 6:26:40 PM PDT by SE Mom (Proud mom of an Iraq war combat vet)
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To: wtd

“If you like your Ebola, you can keep your Ebola.”
If you don’t like your Ebola, keep it anyway.


7 posted on 10/11/2014 6:27:32 PM PDT by gasport (Does the EPA protect the human environment?)
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To: wtd

I understand that the Zaire strain is the worst one. Fatality rates of 90%.


8 posted on 10/11/2014 6:29:04 PM PDT by bubbacluck (America 180)
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To: wtd
The last paragraph:

"Potential reservoirs of EBOV, fruit bats of the species Hypsignathus monstrosus, Epomops franqueti, and Myonycteris torquata, are present in large parts of West Africa. Therefore, it is possible that EBOV has circulated undetected in this region for some time. The emergence of the virus in Guinea highlights the risk of EBOV outbreaks in the whole West African subregion."

9 posted on 10/11/2014 6:52:57 PM PDT by Art in Idaho (Conservatism is the only Hope for Western Civilization.)
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To: wtd

I’m going to get really nerdy and geeky here, and point out that technically, the part you highlighted in red, is using the wrong terminology.

The strain is sort of like “breed” in higher animals. There are 5 strains of Ebola; their genomes are from 30 to 40% different from each other.

The Ebola outbreak in Guinea is only 1.5 to 3% different genetically than Ebola Zaire seen in other outbreaks. By definition, therefore, it is Ebola Zaire. The small genetic differences make it a separate clade, not strain. A clade is a minor variant of an existing virus.


10 posted on 10/11/2014 7:25:18 PM PDT by exDemMom (Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
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Comment #11 Removed by Moderator

To: wtd
Gibberish? There's a lot of plain talk in the paper.

...fruit bats of the species Hypsignathus monstrosus, Epomops franqueti, and Myonycteris torquata, are present in large parts of West Africa. Therefore, it is possible that EBOV has circulated undetected in this region for some time. The emergence of the virus in Guinea highlights the risk of EBOV outbreaks in the whole West African subregion.

IOW, look out for fruit bats.

12 posted on 10/11/2014 7:45:24 PM PDT by ProtectOurFreedom
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To: liege

True but this strain is different. Same family different child. The incubation period seems longer with this strain. Lethality not as high as the original strain.


13 posted on 10/11/2014 7:48:12 PM PDT by Nuc 1.1 (Nuc 1 Liberals aren't Patriots. Remember 1789!)
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To: wtd

Zaire strain. That’s really bad. 75% to 90% fatal.


14 posted on 10/11/2014 8:21:24 PM PDT by BuffaloJack (Bomb ISIS; bomb them again; bomb them again; kill all survivors; take no prisoners.)
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To: Nuc 1.1

They do seem to shift, don’t they.


15 posted on 10/11/2014 8:45:14 PM PDT by bubbacluck (America 180)
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To: exDemMom
I’m going to get really nerdy and geeky here

Thanks for the warning.

16 posted on 10/11/2014 9:12:18 PM PDT by super7man (Oh why did I post that, now I'll never be able to run for Congress.)
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To: liege

They do indeed. But there always seems to be a trade off. The ability of a virus to spread more easily seems to result in a reduction in lethality. Perhaps someone far smarter than us set it up that way.


17 posted on 10/11/2014 9:16:39 PM PDT by Nuc 1.1 (Nuc 1 Liberals aren't Patriots. Remember 1789!)
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To: super7man
Thanks for the warning.

LOL.

18 posted on 10/11/2014 10:03:08 PM PDT by exDemMom (Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
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To: 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; Dog Gone; ...
Ping...

A link to this thread has been posted on the Ebola Surveillance Thread

19 posted on 10/12/2014 7:29:33 AM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing.)
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To: Smokin' Joe

Thanks for the ping!


20 posted on 10/12/2014 9:08:47 PM PDT by Alamo-Girl
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