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Attacking Type 2 Diabetes from a New Direction with Encouraging Results
Rutgers Today ^ | 10/05/14 | Rob Forman

Posted on 10/06/2014 8:40:27 PM PDT by Pining_4_TX

According to Jin, a major cause of insulin resistance is the accumulation of excess fat in the cells of the liver, as well as in muscle tissue. The fat disrupts the process where, ordinarily, insulin would cause body tissues to correctly absorb glucose – blood sugar – and use it as a fuel. With nowhere else to go, much of the excess glucose remains in the bloodstream, where in high concentrations it can damage tissues throughout the body – potentially leading to blindness, kidney damage, cardiovascular diseases and other severe health problems.

“Our goal in this study was to find a safe and practical way of diminishing fat content in the liver. We used mice to perform proof-of-principle experiments in our laboratory,” says Jin. “We succeeded in removing fat, and that in turn improved the animals’ ability to use insulin correctly and reduce blood sugar.”

The modified medication – whose full name is niclosamide ethanolamine salt (NEN) – burned the excess fat in liver cells through a process known as mitochondrial uncoupling. Mitochondria are the microscopic energy source for each cell in the body, and ordinarily – like a well-tuned car engine – they burn fuels including fats and sugars in modest quantities to keep the cells functioning.

(Excerpt) Read more at news.rutgers.edu ...


TOPICS: Health/Medicine
KEYWORDS: diabetes; research
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I don't want to hear from any of you wise guys saying, "Just what the world needs - more healthy mice."
1 posted on 10/06/2014 8:40:27 PM PDT by Pining_4_TX
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To: neverdem

ping


2 posted on 10/06/2014 8:40:49 PM PDT by Pining_4_TX (All those who were appointed to eternal life believed. Acts 13:48)
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To: Pining_4_TX

Type 2 Diabetes is caused by too many carbs. Humans really don’t need to eat carbohydrates, which are really sugars. The real cause of diabetes is know in the scientific literature and these studies are a waste of money.


3 posted on 10/06/2014 8:47:06 PM PDT by captain_dave
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To: Pining_4_TX

How Does Gastric Bypass Surgery Cure Type 2 Diabetes? Doctors aim to ‘bypass the bypass’ by helping the small intestines of diabetes patients get rid of excess glucose.
http://www.healthline.com/health-news/aging-how-gastric-bypass-eliminates-type-2-diabetes-072913

New study: Weight-loss surgery may cure diabetes
http://www.cbsnews.com/news/new-study-weight-loss-surgery-may-cure-diabetes/


4 posted on 10/06/2014 8:47:34 PM PDT by 2ndDivisionVet (The question isn't who is going to let me; it's who is going to stop me.)
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To: Pining_4_TX

Great post!

Thanks!


5 posted on 10/06/2014 8:48:05 PM PDT by Cen-Tejas (it's the debt bomb stupid!)
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To: Cen-Tejas

Was diagnosed T2 in February. A1C 6.9, FBS 140. Three months later I lost 30 pounds. A1C 5.7, FBS 105. Three months later lost 15 more pounds. FBS 73. Go figure. No meds. Just started walking every day and watching what I eat and count calories.


6 posted on 10/06/2014 8:50:58 PM PDT by Tuxedo (Forget Gold - buy Lead!)
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To: 2ndDivisionVet

Gastric bypass is dangerous, and I know people who manage to gain back most or all of the weight they had lost after the surgery. It’s a drastic choice.

http://junkfoodscience.blogspot.com/2007/01/junkfood-science-weekend-special.html


7 posted on 10/06/2014 8:54:28 PM PDT by Pining_4_TX (All those who were appointed to eternal life believed. Acts 13:48)
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To: Cen-Tejas

You’re welcome. :-)


8 posted on 10/06/2014 8:54:55 PM PDT by Pining_4_TX (All those who were appointed to eternal life believed. Acts 13:48)
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To: captain_dave
True about carbs, but I believe fat also plays a role. A large percentage of diabetics are also overweight. Many also develop fatty livers. And of course, high triglycerides are the result of a diet of excess saturated fat and carbs.
9 posted on 10/06/2014 8:57:56 PM PDT by fatnotlazy
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To: 2ndDivisionVet

I won’t go under the knife to lose weight and possibly treat my diabetes. I might feel differently if I was, say, 600 pounds. Most reputable surgeons won’t operate unless the patient is morbidly obese. In that situation, it’s less risky to have the surgery than to lose weight through the slower approach of diet and exercise. However, for the moderately obese and those with a few pounds to lose, the risks of weight loss surgery far outweigh the benefits.


10 posted on 10/06/2014 9:04:32 PM PDT by fatnotlazy
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To: Pining_4_TX

Mitochondria are the microscopic energy source for each cell in the body

They use the Force to treat diabetes


11 posted on 10/06/2014 9:22:50 PM PDT by minnesota_bound
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To: minnesota_bound

Hasn’t it always been that way?

CA....


12 posted on 10/06/2014 9:41:40 PM PDT by Chances Are (Seems I've found that silly grin again....)
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To: Pining_4_TX

Haven’t they already demonstrated that a 600 calorie per day diet for a short duration does this same thing?

While difficult, it seems less risky than drugs or bypass.


13 posted on 10/06/2014 9:42:21 PM PDT by Gingersnap
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To: captain_dave

BINGO! Oldest son is Type 2, and when he gave up the carbs and sugars, he lost weight and takes less meds.

I used his diet, sans the high sugar fruits to lower my cholesterol Tris, already had the LDL under control by getting rid of the bad oils for cooking. Now it’s bake, grill or broil. It also made me lose a few lbs.


14 posted on 10/07/2014 6:00:36 AM PDT by GailA (IF you fail to keep your promises to the Military, you won't keep them to Citizens!)
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To: fatnotlazy

SIL is a big man 6’4”, large boned, type 1, heart issues, back issues, he weighed 400 lbs. He had the type weight loss surgery that lets you loose slowly, he is now down to 200 lbs, which is what he should weigh, off a lot of meds he had to take, and has less back pain. He still works so is quite active. And did not need surgery for saggy skin.

He does have issues eating raw veggies. And must cut his food up real small.


15 posted on 10/07/2014 6:06:15 AM PDT by GailA (IF you fail to keep your promises to the Military, you won't keep them to Citizens!)
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To: fatnotlazy

Fat plays a role only as a symptom of eating too many carbs. You can’t get fat by eating fat. You get fat by eating carbs. The bady stores excess carbs as fat.


16 posted on 10/07/2014 6:31:54 AM PDT by captain_dave
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To: Pining_4_TX

Where is neverdem? I just realized I haven’t been getting pinged to these articles in a while.


17 posted on 10/07/2014 6:37:46 AM PDT by upsdriver (Palin/West '16)
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To: captain_dave
So then I should go out and eat massive amounts of bacon, cheese and other fatty foods and just be concerned about the carbs?

I'm no medical expert, but I think my cardiologist would beg to differ.

18 posted on 10/07/2014 6:49:36 AM PDT by fatnotlazy
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To: Pining_4_TX

Save for later


19 posted on 10/07/2014 7:17:36 AM PDT by Gay State Conservative (Islamopobia:The Irrational Fear Of Being Beheaded)
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To: fatnotlazy

There are cardiologists who would disagree with your cardiologist. Medical opinions vary. :-)


20 posted on 10/07/2014 7:25:27 AM PDT by Marie Antoinette (:)
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