Skip to comments.Branded Curcumin Matches Effects of Prozac on Depression
Posted on 07/28/2013 11:19:21 AM PDT by neverdem
Chester, NJ—A recent clinical trial published in Phytotherapy Research indicated that a high-absorption curcumin (BCM-95 from Dolcas Biotech, based here) had similar effects as a generic form of Prozac (fluoxetine) on depression, sans the adverse effects.
“It is a novel and surprising application for this natural medicine,” said Ajay Goel, Ph.D., Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center and study co-author. “People with depression have higher levels of inflammation in the brain. Also, people with depression have lower levels of neurogenesis in the brain, meaning they make fewer new brain cells than people with no history of depression. Curcumin is both a potent anti-inflammatory agent and a powerful stimulator for neurogenesis.”
The three-pronged study included 60 volunteers diagnosed with major depressive disorder, with 20 people taking either BCM-95 Curcumin (500 mg capsules twice daily); 20 people taking fluoxetine 20 mg daily; or 20 people taking a combination of BCM-95 Curcumin twice daily with fluoxetine once daily. Their level of depression was assessed using the clinically validated Hamilton Rating Scale for Depression (HAM-D17), which is used to evaluate one’s mood, feelings of guilt, feelings of suicide and other symptoms.
After six weeks, the research showed that curcumin was well tolerated by all of the subjects. The proportion of responders with improved depression symptoms was higher in the combination group (77.8%) than in the fluoxetine (64.7%) and the curcumin (62.5%) groups. However, the data also showed that BCM-95 Curcumin worked as well as fluoxetine in terms of changes in the HAM-D17 score from baseline through six weeks of treatment.
The study was the first human clinical indication that Curcumin can be used as an effective and safe treatment for patients with depression, though it cannot be considered a medical treatment at this time.
Published in WholeFoods Magazine, October 2013 (online 7/24/13)
Baylor University study, author is director of epigenetics. Not exactly fruits and nuts.
Whole Foods Magazine? Give me The Journal of the American Medical Association or The New England Journal of Medicine for medical advice any day.
Is one better than the other?
I take Organic India turmeric, about half the “recommended” dose. It has a very noticeable positive effect on my mental processes. Don’t have depression, so cannot comment on that.
Historically, extremely low doses of meds work for me. Higher doses are dangerous.
It not only works, but one doesn't risk becoming addicted to other pain-blocking narcotics.
It is said to help clear arteries .
As I recall, the patient put curcumin in their mouths, but I can’t remember if the article stated exactly the method. But my impression that it was topically applied to the tissue in the mouth.
Heal the sick. Raise the dead. Make little girls talk out of their head....I guess there is no depression in India.
the more exotic the placebo the better... i think there is a faith effect here
well, talking about depression is like talking about fevers. it’s a catch all for what is probably many different things leading to the same distressing symptom.
This requires some pause for reflection.
Please no one talk about regulating curcumin. The FDA is a bureaucratic hell hole. Businesses have shown time and time again that they can regulate themselves.
Please don't prevent those people who label rat poison as curcumin from giving their sons and daughters the Ferraris they crave.
Or at least a drink. Or both.
This sure sounds like a keyhole-viewed, cynical understanding of both medicine and spirituality.
Depression does have a powerful spiritual side. It is a type of self focused hatred. It also is found in many cases to be susceptible to influence (to the worse or to the better) through physical and chemical means.
Talking about depressions as though they were all one illness is like talking about fevers as though they were all one illness.
Yes I plug for a specific faith asserting it identifies a true God. I also know a lot of spiritual rackets or cults make claims about this same God which are palpably false.
How about cutting out the cutesy hints and evasive barbs and actually stating what you believe is the salient wrong. You add about zero information here.
I didn't say that all depressions were the same. I made a statement that various mental conditions were viewed for centuries as sinful failures of character or demonic possession.
Do you disagree with that statement?
Do you believe that everyone is capable of overcoming their mental disorders? Even epileptics?
Do you believe that only sinners are the ones that fail to overcome their mental problems and deserve their fate?
Do you believe that everything is right with a world that includes many people that seem unable to deal with their mental conditions?
Certainly people are over-medicating themselves. Certainly there is the possibility that some mental conditions are the result of toxins in the environment, prenatal poisoning from mothers who smoked/drank/took drugs, etc.
But there seem to be many cases where otherwise good and normal people behave in horrible ways until they start taking the appropriate medication.
What do you make of all this? Do you just sing "Onward Christian Soldier" in a louder voice?
1) God created a physical universe.
2) God created Adam with free will and put all things physical under his authority.
3) Adam abdicated that authority to Satan and Satan corrupted everything.
Q.E.D. You can’t blame the existence of cancer, tornadoes, bot flies, and entropy on God unless you’re thereby affirming a preference for having been created without a will of your own.
I could write all night.
Demonic possession, when it was thought to have happened, was not considered a fault of the, ah, possessee — unless s/he had called on the demon.
For around 500 years the normal Catholic official wisdom about possession was that one should only conclude that when medical reasons had been ruled out. The failures were in the undeveloped natural philosophies. The theoretical/theological side was pretty much in order.
However, it IS true that there remain some superstitious jerks among Christians.
I would not say that ALL “defects of will” can be medicated away. For example, you're the second person I've encountered today who has based some negative opinions about the Church on ignorance of what the Church officially teaches and prescribes. I don't think there is yet a medicine to address basing judgments on what amounts to poorly substantiated or unsubstantiated rumor.
I WILL say this about the generosity and compassion of the modern scientists dubious about theism generally and Christians specifically:
When my kid was 15 months old, I was told she would die a slow and lingering death as a destructive epilepsy trashed her brain. (At least some of the scientists were wrong on that one. She turns 30 this November.)
At the time I was an Episcopal priest. (I am now a Catholic lay-D00d.) We had recourse to the local pediatric neurology gods, among whom was a certain Dr. Dreyfus. The usual routine was that he would schedule an appointment right slap in the middle of nap time. Then he would be 45 minutes late. Then, when my kid cried as he examined her, he would call her “spoiled.”
So,one day I showed up with my kid, and I had come from “work” so I was wearing my “clericals” (black suit and shirt, backwards collar.) This meant that I got to listen to how Christians in the middle ages thought epilepsy was demonic and were just SEW superstitious and all.
While my kid was, according to him, dying.
I'm sure there is some good, scientific, anti-church explanation about why, when a father's only child is dying it is good to call him a jerk.
Yeah, those journals, bought and paid for by Big Pharma, are really helpful....if all you do for your health is continue courses of Big Pharma drugs! You know, the kind with the list of side effects 3-4 pages long?
Hey, the Luke who wrote the gospel and Acts was also a physician and did not stop being one when he became a believer in Jesus. Folks who say doctors have no place in Christian ministry are just being silly.
Well, how about looking at my own freep page. I don’t think you will read that as just a louder version of “Onward Christian Soldiers” (as helpful as that hymn can be in the appropriate circumstance, it is not a comprehensive gospel message).
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