The one thing I cannot do is read a full book on a screen. I need to be able to physically touch the pages and smell the printed scent. Nothing is more wonderful to me than to be able to go through the pages of a book. The local used bookstore looks like it does quite well as far as customer base.
You can "index" search to find certain topics but then you have to "slide, slide, slide" a page to actually read the text. My eyes can scan a paper page much quicker than an e-page and when artwork or photography is involved, forget it. It isn't the same experience.
It is a different experience to hold an issue of Life Magazine in your hands (or in my case a bound volume of issues, bought at a library book sale). The printing techniques never duplicate the effect on screen and the sheer size of the page is something else to take in.