In a superplague, the effete Liberals would be the first to perish. Urban areas and defenseless college towns will be easy picking for the roving gangs trying to survive.
Seriously, for a true ‘super plague’ to work it would need a very, very long incubation time maybe six month’s or so, with no obvious symptoms yet be communicable for most of that incubation period.
That way the majority of the targeted populace would be infected before discovery by the ‘authorities’.
Anything less could be held at bay by total isolation until the plague burned itself out. A lot of Science Fiction and medical thriller writers have thought long and hard about it.
But as someone else said a psychological plague as evidenced by advocating a type of anything goes/no consequence lifestyle would work. It just takes a lot longer, possibly over several generations. Which is what we are seeing now.
The question now is, ‘Is this curable?’ and if so are we willing to apply the treatment to cure it?