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Anthracimycin: New Antibiotic Kills Anthrax, MRSA
Sci-News.com ^ | Jul 19, 2013 | NA

Posted on 08/04/2013 1:55:42 PM PDT by neverdem

Scientists have discovered a marine microbe-derived antibiotic that has the ability to kill the deadly Anthrax bacterium Bacillus anthracis and other pathogens such as the methicillin-resistant Staphylococcus aureus.

Bacillus anthracis spores as viewed in scanning electron microscopy (© National Academy of Engineering)

Bacillus anthracis spores as viewed in scanning electron microscopy (© National Academy of Engineering)

Prof William Fenical with colleagues from the University of California San Diego’s Scripps Institution of Oceanography first collected Streptomyces sp. - a marine microorganism that produces the compound – in 2012 from sediments close to shore off Santa Barbara, California.

Using an analytical technique known as spectroscopy, they then deciphered the unusual structure of a molecule isolated from Streptomyces sp. Initial testing of the compound, which they named Anthracimycin, revealed its potency as a killer of anthrax and the methicillin-resistant Staphylococcus aureus (MRSA).

“The real importance of this work is the fact that Anthracimycin has a new and unique chemical structure,” explained Prof Fenical, who is a senior author of a paper reporting the discovery in the journal Angewandte Chemie.

Structure of Anthracimycin from X-ray crystal structure analysis. Bottom right: chemical structure of Anthracimycin (Kyoung Hwa Jang et al)

Structure of Anthracimycin from X-ray crystal structure analysis. Bottom right: chemical structure of Anthracimycin (Kyoung Hwa Jang et al)

“The finding is a basic research discovery, which could lead to testing and development, and eventually a drug.”

“The discovery of truly new antibiotic compounds is quite rare. This discovery adds to many previous discoveries that show that marine bacteria are genetically and chemically unique.”

“The discovery provides the latest evidence that the oceans, and many of its unexplored regions, represent a vast resource for new materials that could one day treat a variety of diseases and illnesses,” Prof Fenical concluded.

______

Bibliographic information: Kyoung Hwa Jang et al. 2013. Anthracimycin, a Potent Anthrax Antibiotic from a Marine-Derived Actinomycete. Angewandte Chemie, vol. 52, no 30, pages 7822–7824; doi: 10.1002/anie.201302749


TOPICS: Health/Medicine; Science
KEYWORDS: anthracimycin; microbiology; newantibiotic
That's another way to depict the structure of the molecule.

Molecular Formula: C25H32O4

Carbon atoms are at each angle except for that lone oxygen that's part of the extended ring structure. There are three oxygen atoms off of the extended ring structure.

Hydrogen atoms are understood. Carbon atoms are bound to four other atoms except when they have covalent double or triple bonds. Covalent bonds mean atoms share two or more pairs of electrons.

Anthracimycin's carbon atoms only have single or double covalent bonds. Single covalent bonds are represented by single lines; double bonds are represented by two lines, etc.

1 posted on 08/04/2013 1:55:42 PM PDT by neverdem
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To: neverdem

Wow, what an exciting discovery. Our lives just changed and most of us remain blissfully unaware.


2 posted on 08/04/2013 2:05:49 PM PDT by Owl558 (Those who remember George Santayana are doomed to repeat him)
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To: neverdem

May go down in history as the last medical innovation before ObamaCare completely strangled all incentives for research.


3 posted on 08/04/2013 2:10:45 PM PDT by Spok
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To: Owl558; All
Covalent bonds mean atoms share two or more pairs of electrons.

Covalent bonds mean at least two atoms share one or more pairs of electrons.

4 posted on 08/04/2013 2:12:14 PM PDT by neverdem (Register pressure cookers! /s)
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To: Owl558; Spok
Wow, what an exciting discovery.

I just made a new keyword, i.e. newantibiotic. What's really interesting here is that this antibiotic came from bacteria, IMHO. Our usual experience is to discover these drugs in fungi. Penicillin was discovered accidentally in an old mold culture by Alexander Fleming.

5 posted on 08/04/2013 2:21:57 PM PDT by neverdem (Register pressure cookers! /s)
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To: neverdem

“At first, we thought it was safe. A new antibiotic! It was a breakthrough! It was only later that we learned what the side effect was. Anyway, Son, that’s how zombies were created ...”


6 posted on 08/04/2013 2:25:11 PM PDT by ClearCase_guy (21st century. I'm not a fan.)
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To: ClearCase_guy

I would be Jimmy10Toes again if it came out three years ago.


7 posted on 08/04/2013 2:27:48 PM PDT by Jimmy4Toes
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To: neverdem

“What’s really interesting here is that this antibiotic came from bacteria...”

It’s a seminal breakthrough that gives us a whole new way of looking at antibiotic chemistry. Real Nobel Prize stuff, if that still means anything. We get to go back and search other coastal areas for variations of this molecule.

“Penicillin was discovered accidentally in an old mold culture by Alexander Fleming.”

If I remember the story, he became interested in a blue mold growing on some orange peels left out near a window.

(and if that isn’t the story, it should be :)


8 posted on 08/04/2013 2:33:51 PM PDT by Owl558 (Those who remember George Santayana are doomed to repeat him)
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To: neverdem

In sediment off shore from Santa Barbara.

Could this be from OIL seepage?


9 posted on 08/04/2013 3:05:03 PM PDT by Scrambler Bob ( Concerning bo -- that refers to the president. If I capitalize it, I mean the dog.)
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To: neverdem

Quick. Put it in hand soap.


10 posted on 08/04/2013 3:08:56 PM PDT by BenLurkin (This is not a statement of fact. It is either opinion or satire; or both.)
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To: neverdem
Perhaps it could be used prophylactically,
Both MSSA and MRSA are hospital acquired

11 posted on 08/04/2013 3:11:35 PM PDT by Uri’el-2012 (Psalm 119:174 I long for Your salvation, YHvH, Your teaching is my delight.)
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To: neverdem

Thanks for posting this. I have not seen it anywhere else. A family member almost died from a MRSA infection last year.


12 posted on 08/04/2013 3:12:31 PM PDT by LongWayHome
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To: yefragetuwrabrumuy; Mother Abigail; vetvetdoug; Smokin' Joe; Global2010; Battle Axe; ...
Bloody diarrhea outbreak linked to Mexican food restaurant

Qantas Flight To Australia Becomes Poop Plane From Hell

FReepmail me if you want on or off my combined microbiology/immunology ping list.

13 posted on 08/04/2013 3:13:33 PM PDT by neverdem (Register pressure cookers! /s)
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You are Free Republic!!!
Please Contribute Today!

14 posted on 08/04/2013 3:16:59 PM PDT by RedMDer (http://www.dontfundobamacare.com/)
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To: Owl558

http://en.wikipedia.org/wiki/Alexander_Fleming#Accidental_discovery


15 posted on 08/04/2013 3:17:16 PM PDT by neverdem (Register pressure cookers! /s)
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To: ClearCase_guy

Like.


16 posted on 08/04/2013 3:23:49 PM PDT by savedbygrace (But God.)
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To: UriĀ’el-2012
Perhaps it could be used prophylactically,

No way after toxicity testing. This needs to be used, if possible, very judiciously, or else we'll promote antibacterial resistance to it.

Both MSSA and MRSA are hospital acquired

Both are also community acquired already.

17 posted on 08/04/2013 3:25:22 PM PDT by neverdem (Register pressure cookers! /s)
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To: neverdem

MRSA. Is killed by lavender oil.


18 posted on 08/04/2013 3:27:02 PM PDT by aMorePerfectUnion (The more corrupt the state, the more numerous the laws - Tacituss)
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To: UriĀ’el-2012
Both MSSA and MRSA are hospital acquired

Back in August 2009 I had not been near a hospital in about a decade. I caught a case of MRSA in my armpit and ended up at Dewitt Army Hospital in serious condition for four days.

The doctors told me MRSA is now everywhere and they think close to 50% of the population have it on their bodies. It just takes the right conditions, including the host being ill and their defenses being down for the infection to attack.

19 posted on 08/04/2013 3:28:17 PM PDT by OldMissileer
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To: OldMissileer

A relative of mine was on a hike ...slipped on some rocks and scraped his shin up pretty good. He almost lost that leg to MRSA ... they cleaned it out to the bone ... if it had been in the bone, bye-bye leg. It took months to heal and required a wound specialist’s care.


20 posted on 08/04/2013 3:50:43 PM PDT by MissMagnolia (You see, truth always resides wherever brave men still have ammunition. I pick truth. (John Ransom))
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To: neverdem
in 2012 from sediments close to shore off Santa Barbara, California

Sediments from an environment that has continuous oil seeps from the sea floor that put oil tar on the beach sands. This is awful. In this case we must plug the oil seeps, vacuum up all the sediments, store them safely underground forever and walk away from this discovery, lest the oil companies possibly get favorable reflected publicity from such a discovery. Yes, people will die, but oil companies getting favorable reflected publicity from such a discovery is worse. You can't make an omelette without breaking a few eggs. (/liberal)

21 posted on 08/04/2013 3:52:25 PM PDT by 17th Miss Regt
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To: neverdem; OldMissileer
U-2012>Both MSSA and MRSA are hospital acquired

Both are also community acquired already.

The literature would suggest it is primarily acquired in hospitals.

I went in the hospital this year for what I thought was
a routine aortic valve replacement.

I acquired MSSA in my sternum,
MSSA ate the sternum;
it had to be removed.

Twelve weeks four times a day of the most
exotic antibiotics to kill the Staph infection.

Thirty-eight doctors said I was going to die,
one Infectious Disease Doctor saved my life.

I had been told I would be in the hospital for 8 - 10 day;
It was four months and six operations.

I can no longer ride in a car with an air bag.


22 posted on 08/04/2013 3:52:47 PM PDT by Uri’el-2012 (Psalm 119:174 I long for Your salvation, YHvH, Your teaching is my delight.)
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To: neverdem

Bump!


23 posted on 08/04/2013 4:00:07 PM PDT by EternalVigilance
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To: neverdem
Of course when a generic knockoff (probably an illegal one) becomes cheap enough to be sold in Mexico,Nigeria and Indonesia worldwide,and complete,resistance will occur overnight.
24 posted on 08/04/2013 4:04:24 PM PDT by Gay State Conservative (If Obama Had A City It Would Look Like Detroit.)
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To: Owl558
“What’s really interesting here is that this antibiotic came from bacteria...”

Streptomycin the first antibiotic remedy for tuberculosis was first isolated from the actinobacterium Streptomyces griseus on October 19, 1943, by Albert Schatz, a graduate student, in the laboratory of Selman Abraham Waksman at Rutgers University.
25 posted on 08/04/2013 4:15:03 PM PDT by Hiddigeigei ("Talk sense to a fool and he calls you foolish," said Dionysus - Euripides)
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To: Dark Wing

ping


26 posted on 08/04/2013 5:48:33 PM PDT by Thud
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To: 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; Dog Gone; ...

Ping! (thanks, neverdem!)


27 posted on 08/04/2013 5:52:44 PM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
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To: neverdem

It stands to reason that sooner or later a bacillus would use chemical warfare against the competition...maybe there are more antibiotics out there that fit the same mold (no pun intended).


28 posted on 08/04/2013 5:54:40 PM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
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To: Smokin' Joe

Thanks for the ping!


29 posted on 08/04/2013 7:10:39 PM PDT by Alamo-Girl
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To: Smokin' Joe

msra me!

grand discovery!


30 posted on 08/04/2013 7:50:27 PM PDT by bitt
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To: MissMagnolia
It took months to heal and required a wound specialist’s care.

I was lucky. It started like a pimple and then grew to the size of a golf ball. This was the worst pain I have ever had and I have had many injuries due to football, hockey, rock climbing, and several other stupid things young people do.

Anyway, the infection stayed above the muscle and spread over the left side of my chest in less than two days. My daughter drove me to Dewitt and I actually thought I would not make it there alive.

I have a small indentation in my armpit where the doctors opened the wound after two days of heavy antibiotics. I was truly blessed.

31 posted on 08/04/2013 8:14:40 PM PDT by OldMissileer
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To: Alamo-Girl

You’re Welcome, Alamo-Girl!


32 posted on 08/04/2013 8:42:03 PM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
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To: ClearCase_guy

Revers.

We put the chemical in the water and food supply, and nobody knew, or could have predicted the result.

Revers.


33 posted on 08/05/2013 9:30:00 AM PDT by RinaseaofDs
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