In my house, I keep my .357 loaded with glaser rounds in case of an intruder. I may get a 12 gauge for home defense one of these days.
I carry .357 snubby with .38+P defense ammo. But I keep a .45 and short barreled shotty in the bedroom for home defense.
10MM just gives a lot more rounds, I think.
I am of the point of view that the .45 is the best fighting instrument known to mankind and a fast-opening pistol safe with a cypher lock is the best chance to keep the kids away from the home defense beast.
I keep my .357 loaded with 38 special hollow points for in-home. Have 4 speed loaders and have 38 special in 2 and .357 in the other 2. Also have a 12 gauge but would hate to have to fire it (or even the .357) indoors w/o time to put on ear muffs....