I don't feel any guilt either. My ancestors were Scott's Irish/German, and immigrated well before WW1, but weren't even in this country during the time of the Indian “genocide”. I'd say that we are already healed.
I'll just mention that the Government totally disrupted the life in the Appalachian area supposedly for the benefit of the citizens living in less than perfect conditions, but actually because developers wanted their land and trees. By and large white folks IIRC. And don't forget that the Irish were facing a lot of discrimination.
A student once said to my husband, you are just punishing me cause I'm black. My husband told him, "I don't want to hear your complaints about white men and prejudice. The white man killed and scalped my ancestors. Get over it." Learn the past, but don't live there. What I say is: Live in the pressent, and do right. This will anger some people and astonish the rest. Can't remember who said some of that.